Moguće interakcije s lijekovima

Ako koristite bilo koji od dolje navedenih lijekova/pripravaka, ne preporuča se da uzimate vitaminske pripravke s biotinom bez dozvole liječnika.

Antibiotici – Biotin proizvode crijevne bakterije, no ne zna se još koliko je moguća apsorpcija istog u ljudi. Međutim, teoretski je moguće da dugotrajna upotreba antiobiotika uzrokuje nedostatak biotina.[1-3]

Antidijabetici – Kombinacija kromova pikolinata i biotina te standardnog liječenja šećerne bolesti omogućuje bolju kontrolu glukoze u pretilih i oboljelih od dijabetesa tipa 2.[4,5]

Antikonvulzivi – Dugotrajno uzimanje antikonvulziva, kao što su primidon, karbamazepin, valproična kiselina, fenitoin i fenobarbital, smanjuje količine biotina u organizmu. Primidon i karbamazepin inhibiraju apsorpciju biotina, dok valproična kiselina uzrokuje smanjenu aktivnost biotinidaze u djece. Također, karbamazepin, fenitoin i fenobarbital pojačavaju katabolizam biotina, što može rezultirati nedostatkom ovog vitamina.[6-11]

Antilipemici – Kombinacija kromova pikolinata i biotina te standardnog liječenja šećerne bolesti poboljšava omjer triglicerida i lipoproteina u organizmu.[4,12]

Izotretinoin – Izotretinoin, derivat vitamina A, može smanjiti aktivnost biotinidaze, što može uzrokovati nedostatak biotina u organizmu.[13]

Topikalni kortikosteroidi – Kombinacija topikalnih kortikosteroida, cinka i biotina pomaže djeci koja pate od gubitka kose (alopecia areata).[14]

Interakcije vitamina B5 s hranjivim tvarima

Pantotenska kiselina (Vitamin B5) – Biotin dijeli multivitaminski prijenosni sustav s vitaminom B5 što bi teoretski moglo smanjiti apsorpciju biotina. Naime, velike doze pantotenske kiseline mogu uzrokovati malapsorpciju biotina, a time i nedostatak biotina u organizmu. Zabilježen je jedan slučaj eozinofilnog pleuroperikarditisa uslijed uzimanja vitamina B5 i biotina, koji se povlači s prestankom uzimanja ove kombinacije vitamina.[15-18]

Avidin – Avidin je protein u jajima koji veže biotin čime se sprječava apsorpcija biotina.[17,19]

Lipoična kiselina – Biotin dijeli multivitaminski prijenosni sustav s ovom kiselinom što bi teoretski moglo smanjiti apsorpciju biotina. Pokazalo se da farmakološke količine lipoične kiseline smanjuju aktivnost biotin-ovisnih enzima.[17,20]

"Literatura"

1. Halevy, S., Diamant, E.J., Guggenheim, K. (1955) The Effect of Antibiotics on the Metabolism of Nicotinic Acid, Biotin and Folic Acid in Rats. Br. J.Nutr. 9, 57-62.

2.  Burkholder, P.R., McVeigh, I. (1942) Synthesis of vitamins by intestinal bacteria. Proc. Natl. Acad. Sci. USA 28, 285-289.

3. Bender, D.A. (2003) Nutritional biochemistry of the vitamins, Cambridge University Press, Cambridge.

4. Singer, G.M., Geohas, J. (2006) The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol. Ther. 8, 636-643.

5. Albarracin, C.A., Fuqua, B.C., Evans, J.L., Goldfine, I.D. (2008) Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. Diabetes Metab. Res. Rev. 24, 41-51.

6. Mock, D.M., Dyken, M.E. (1997) Biotin catabolism is accelerated in adults receiving long-term therapy with anticonvulsants.Neurology. 49, 1444–1447.

7. Mock, D.M., Mock, N.I., Nelson, R.P., Lombard, K.A. (1998) Disturbances in biotin metabolism in children undergoing long-term anticonvulsant therapy. J. Pediatr. Gastroenterol. Nutr. 26, 245–250.

8. Krause, K.H., Bonjour, J.P., Berlit, P., Kochen, W. (1985) Biotin status of epileptics. Ann. NY Acad. Sci. 447, 297–313.

9. Krause, K.H., Bonjour, J.P., Berlit, P. i sur. (1988) Effect of long-term treatment with antiepileptic drugs on the vitamin status. Drug Nutr. Interact. 5, 317–343.

10. Said, H.M., Redha, R., Nylander, W. (1989) Biotin transport in the human intestine: inhibition by anticonvulsant drugs. Am. J. Clin. Nutr. 49, 127–131.

11. Schulpis, K.H., Karikas, G.A., Tjamouranis, J., Regoutas, S., Tsakiris, S. (2001) Low serum biotinidase activity in children with valproic acid monotherapy. Epilepsia. 42, 1359-1362.

12. Geohas, J., Daly, A., Juturu, V., Finch, M., Komorowski, J.R. (2007) Chromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Am. J. Med. Sci. 333, 145-153.

13. Schulpis, K.H., Georgala, S., Papakonstantinou, E.D., Michas, T., Karikas, G.A. (1999) The effect of isotretinoin on biotinidase activity. Skin Pharmacol. Appl. Skin Physiol. 12, 28-33.

14. Camacho, F.M., Garcia-Hernandez, M.J. (1999) Zinc aspartate, biotin, and clobetasol propionate in the treatment of alopecia areata in childhood. Pediatr. Dermatol. 16, 336–338.

15. Zempleni, J., Mock, D.M. (1999) Human peripheral blood mononuclear cells: Inhibition of biotin transport by reversible competition with pantothenic acid is quantitatively minor. J. Nutr. Biochem. 10, 427-432.

16. Said, H.M., Ortiz, A., McCloud, E. i sur. (1998) Biotin uptake by human colonic epithelial NCM460 cells: a carrier-mediated process shared with pantothenic acid. Am. J. Physiol. 275, C1365-C1371.

17. Zempleni, J., Wijeratne, S.S.K., Hassan, Y.I. (2009) Biotin. Int. Union Biochem. Mol. Biol. 35, 36–46.

18. Debourdeau, P.M., Djezzar, S., Estival, J.L., Zammit, C.M., Richard, R.C., Castot, A.C. (2001) Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann. Pharmacother. 35, 424-426.

19. Hiller, Y., Gershoni, J.M., Bayer, E.A., Wilchek, M. (1987) Biotin binding to avidin: Oligosaccharide side chain not required for ligand association. Biochem. J. 248, 167-171.

20. Zempleni, J., Trusty, T.A., Mock, D.M. (1997) Lipoic Acid Reduces the Activities of Biotin-Dependent Carboxylases in Rat Liver. J.Nutr. 127, 1776-1781.