Moguće interakcije s lijekovima

Ako koristite bilo koji od dolje navedenih lijekova/pripravaka, ne preporuča se da uzimate dodatne mineralne pripravke s natrijem bez dozvole liječnika.

ACE inhibitori – Ovi lijekovi, kao što su kaptopril, lizinopril i enalapril, mogu uzrokovati nedostatak natrija, tj. hiponatremiju.[1-5]

Antipsihotici – Ovi se lijekovi, kao što su haloperidol, amitriptilin, flufenazin i olanzapin, povezuju s hiponatremijom.[6-12]

Ciklofosfamid – Ovaj lijek koji se koristi u liječenju raka i nekih autoimunih bolesti ima antidiuretički učinak zbog kojeg može uzrokovati dilucijsku hiponatremiju i intoksikaciju vodom.[13-15]

Cisplatin – Ovaj lijek koji se koristi u liječenju raka može uzrokovati nedostatak natrija, tj. hiponatremiju u 4 do 10 % slučajeva.[16-18]

Derivati sulfonilureje – Ovi lijekovi koji se koriste u liječenju šećerne bolesti mogu uzrokovati hiponatremiju u 6 do 10 % slučajeva. Također, mogu uzrokovati sindrom neprimjerenog lučenja antidiuretičkog hormona (eng. Syndrome of Inappropriate Secretion of Antidiuretic Hormone, SIADH).[19-21]

Desmopresin – Ovaj lijek, koji se koristi u liječenju centralnog dijabetesa insipidusa i koji djeluje kao prirodni hormon vasopresin, može uzrokovati hiponatremiju.[22-25]

Diuretici Henleove petlje i tiazidni diuretici – Glavna svrha navedenih diuretika jest da ometaju reapsorpciju natrija (i klorida) u bubrezima, čime se povećava njegovo izlučivanje iz organizma. S obzirom da je smanjenje razina natrija „namjerno“, ne preporuča se dodatno uzimanje soli, tj. natrijeva klorida.[20,26-29]

Diuretici koji štede kalij – Ovi lijekovi, kao što je amilorid, spironolakton i triamteren, smanjuju razine natrija u organizmu povećavajući njegovo izlučivanje urinom, tj. inhibirajući njegovu reapsorpciju u bubrezima.[30-34]

Kortikosteroidi – Steroidni proutuuplani lijekovi mogu povećati zadržavanje natrija i time povećati njegove razine u našem organizmu, tj. uzrokovati hipernatremiju.[20,35,36]

Litij – Tijekom prvog dana uzimanja litij može povećati urinarno izlučivanje natrija. Međutim, daljnjih 4 do 5 dana razine se natrija mogu povisiti zbog povećanja zadržavanja natrija u organizmu. Također, promjene u unosu natrija mogu utjecati na eliminaciju litija u bubrezima.[20,37,38]

Nesteroidni protuupalni lijekovi – Ovi lijekovi, kao što su ibuprofen i naproksen, mogu uzrokovati hiponatremiju.[37,39,40]

Vinkristin – Ovaj lijek koji se koristi u kemoterapiji može uzrokovati hiponatremiju.[41-44]

Interakcije natrija s hranjivim tvarima

Kalcij Veći unos natrija može povećati urinarno izlučivanje kalcija.[45-51]

Kalij – Kalij može povećati urinarno izlučivanje natrija, tako što smanjuje njegovu reapsorpciju u distalnom tubulu bubrega.[45-51]

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