Moguće interakcije s lijekovima
Ako koristite bilo koji od dolje navedenih lijekova/pripravaka, ne preporuča se da uzimate vitaminske pripravke s vitaminom B5 bez dozvole liječnika.
Antibiotici – Pantotenska kiselina može ometati djelovanje i učinkovitost nekih antibiotika, kao što su aureomicin, eritromicin i streptomicin. Pretpostavlja se da ovi antibiotici inhibiraju enzime uključene u biosintezu pantotenske kiseline u mikroorganizmima. Međutim, poznato je da su mučnina, povraćanje i vrtoglavica česte nuspojave streptomicina, a pojedina istraživanja pokazuju da pantotenska kiselina može smanjiti ove nuspojave, dok druga ne nalaze takvu povezanost. Analozi pantotenske kiseline, N-supstituirani pantotenamidi i antimetaboliti, kao što su N-pentilpantotenamid i N-heptilpantotenamid, imaju antibiotičko djelovanje i istražuju se kao potencijalni novi antibiotici.[1-9]
Cisplatin – Istraživanja pokazuju da pantotenska kiselina može spriječiti gluhoću izazvanu cisplatinom, lijekom koji se koristi u kemoterapiji.[9,10]
Kortikosteroidi – Istraživanja pokazuju da bi pantotenska kiselina mogla povećati djelovanje kortikosteroida.[9,11]
Oralni kontraceptivi – Oralni kontraceptivi koji sadrže estrogen i progestin povećavaju potrebu za pantotenskom kiselinom.[9,12]
Valproična kiselina – Istraživanja pokazuju da pantotenska kiselina može smanjiti nuspojave uzrokovane valproičnom kiselinom, antiepileptikom.[9,13,14]
Interakcije vitamina B5 s hranjivim tvarima
Biotin – Poznato je da biotin (vitamin H) i pantotenska kiselina dijele isti mehanizam apsorpcije u crijevima. Međutim, in vitroistraživanja pokazuju da visoke koncentracije pantotenske kiseline mogu izazvati inhibiciju apsorpcije biotina. Potrebna su daljnja in vivo istraživanja koja bi potvrdila ili opovrgnula ovakav učinak visokih koncentracija pantotenske kiseline na apsorpciju biotina. Također, biotin je bitan za uspješnu upotrebu pantotenske kiseline.[9,15,16]
Vitamini B skupine –Vitamini B6, B9 i B12 su potrebni za uspješnu upotrebu pantotenske kiseline u raznim biokemijskim putevima.[16-18]
Vitamin C – Istraživanja pokazuju da vitamin C (askorbinska kiselina) smanjuje simptome nedostatka pantotenske kiseline.[9,19,20]
"Literatura"
1. Foster, J.W., Pittillo, R.F. (1953) Metabolite reversal of antibiotic inhibition, especially reversal of aureomycin inhibition by riboflavin. J. Bacteriol. 66, 478-486.
2. Lichstein, H.C., Gilfillan, R.F. (1951) Inhibition of pantothenate synthesis by streptomycin. Proc. Soc. Exp. Biol. Med. 77, 459-461.
3. Johnston, R.N., Smith, D.H., Ritchie, R.T., Lockhart, W. (1964) Prolonged streptomycin and isoniazid for pulmonary tuberculosis. Brit. Med. J. 1, 1679-1683.
4. LaCaille, R.A., Prigot, A. (1958) The clinical trial of streptomycin pantothenate in the treatment of soft tissue infections. Am. J. Surg. 95, 963-966.
5. Strauss, E., Begley, T.P. (2002) The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme A, a coenzyme A antimetabolite. J. Biol. Chem. 277, 48205-48209.
6. Thomas, J., Cronan, J.E. (2010) Antibacterial activity of N-pentylpantothenamide is due to inhibition of coenzyme A synthesis. Antimicrob. Agents Chemother. 54, 1374-1377.
7. Virga, K.G., Zhang, Y.M., Leonardi, R. i sur. (2006) Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors. Bioorg. Med. Chem. 14, 1007-1020.
8. Zhang, Y.M., Frank, M.W., Virga, K.G. i sur. (2004) Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites. J. Biol. Chem. 279, 50969-50975.
9. Kelly, G.S. (2011) Pantothenic acid. Altern. Med. Rev. 16, 263-274.
10. Ciges, M., Fernandez-Cervilla, F., Crespo, P.V., Campos, A. (1996) Pantothenic acid and coenzyme A in experimental cisplatin induced ototoxia. Acta Otolaryngol. 116, 263-268.
11. Jaroenporn, S., Yamamoto, T., Itabashi, A. i sur. (2008) Effects of pantothenic acid supplementation on adrenal steroid secretion from male rats. Biol. Pharm. Bull. 31, 1205-1208.
12. Lewis, C.M., King, J.C. (1980) Effect of oral contraceptives agents on thiamin, riboflavin, and pantothenic acid status in young women. Am. J. Clin. Nutr. 33, 832-838.
13. Dawson, J.E., Raymond, A.M., Winn, L.M. (2006) Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice. Toxicol. Appl. Pharmacol. 211, 124-132.
14. Thurston, J.H., Hauhart, R.E. (1992) Amelioration of adverse effects of valproic acid on ketogenesis and liver coenzyme A metabolism by cotreatment with pantothenate and carnitine in developing mice: possible clinical significance. Pediatr. Res.31, 419-423.
15. Said, H.M., Ortiz, A., McCloud, E. i sur. (1998) Biotin uptake by human colonic epithelial NCM460 cells: a carriermediated process shared with pantothenic acid. Am. J. Physiol. 275, C1365-C1371.
16. Bender, D.A. (2003) Nutritional biochemistry of the vitamins, Cambridge University Press, Cambridge.
17. Hui, Y.H. (1991) Encyclopedia of food science and technology, John Wiley and sons, Inc., New York.
18. Macrae, R., Robinson, R.K., Sadler, M.J. (1993) Encyclopaedia of food science, food technology and nutrition, Academic Press, London.
19. Barboriak, J.J., Krehl, W.A. (1957) Effect of ascorbic acid in pantothenic acid deficiency. Online: http://jn.nutrition.org/content/63/4/601.full.pdf.
20. Everson, G., Northrop, L., Chung, N.Y., Getty, R. (1954) Effect of ascorbic acid on rats deprived of pantothenic acid during pregnancy. J. Nutr. 54, 305-311.